Woodchucks infected with the woodchuck hepatitis virus (WHV) serve as an animal model for human hepatocellular carcinoma (HCC) induced by the hepatitis B virus (HBV). This model exhibits similarities to human hepatocarcinogenesis and allows the development of multiple tumors at different stages. The woodchuck's vascular architecture enables catheterization with human-sized products, facilitating preclinical research to improve imaging (ultrasound, MRI, PET) and ablation techniques (embolization, radiotherapy). Additionally, interventions like chemo, gene, and immune therapy can be evaluated. Currently, research is being conducted to investigate the similarity of prostate-specific membrane antigen (PSMA) expression in the woodchuck model to that in human liver cancer. Understanding the PSMA expression patterns in this model can provide valuable insights into its role as a diagnostic marker and potential therapeutic target in HCC. This research aims to bridge the gap between the woodchuck model and human liver cancer, advancing our understanding of PSMA-related mechanisms and facilitating the development of novel treatment approaches