Carla Coffin
cscoffin@ucalgary.ca
In-person interactions impact on HCV, HIV, and Syphilis Rates in At Risk Populations
Targeting the hepatitis B virus covalently closed circular DNA genome using a G-quadruplex specific single domain antibody
HDV is uncommon in Toronto but can have an aggressive clinical course: interim analysis
Biologiste Médical
Impact of COVID-19 pandemic–related measures on testing for hepatitis B in British Columbia, Canada: an interrupted time series analysis
Clinical Science Advances in Hepatitis B (HDV, HCV, HIV Co-infections): A Comprehensive Review
Epidemiology and Public Health Implications of Hepatitis B, HDV, HCV, and HIV Co-infections
EPIDEMIOLOGY, TREATMENT PATTERN, AND SURVIVAL IN CANADIAN PATIENTS WITH CHRONIC HEPATITIS B RELATED HEPATOCELLULAR CARCINOMA
HCC RISK STRATIFICATION USING RANDOM SURVIVAL FORREST MACHINE LEARNING MODEL OUTPERFORMS TRADITIONAL ANALOG SCORING
Hepatitis B core antibody is associated with liver fibrosis in people with HIV independently of MASLD
Initial HBV-Hepatocyte Genomic Integrations, Their Formation and Potential Role in Oncogenesis
Investigating HDV screening rates and associated demographic characteristics among first-time HBV positive patients in Alberta from 2018-2022
Compassionate use of REP 2139-Mg in HBV / HDV / HIV co-infection: a first Canadian experience
Functional cure of chronic HBV infection
Using discrete field documentation in Epic EMR for clinical research of hepatitis B
A DNA knot not like any other - exploring the specificity of HBV’s promoter G4-quadruplex
Intravital Imaging of the Liver Microenvironment in The Woodchuck Model of Hepatitis B Virus Infection
Chronic HBV infection in Toronto, Canada: Tale of two clinics
Demographic Characteristics of Hepatitis B-Infected Sub-Saharan African Immigrants in Canada.
Determining a Hepatitis Delta virus (HDV) peptidomimetic therapeutic to target Hepatitis B virus (HBV)
Anchoring Hepatitis B: Investigation of HBV promoter binding with zinc finger Specificity protein 1 and G4-quadruplex binding drugs
Epidemiology and Natural History of Chronic Hepatitis B in the Canadian Province of Alberta from 2012 to 2021: A Population-based Study
Epidemiology, Linkage to Care and Natural History of Women of Childbearing Age with Chronic Hepatitis B: A Population-based Study
Defining a Hepatitis D Virus Antibody Testing Algorithm for Accurate Screening
IL-2 Produced by HBV-specific T cells as a Biomarker of Viral Control and Predictor of Response to PD-1 Therapy Across Clinical Phases of Chronic Hepa
Next Generation Sequence (NGS) Analysis for Hepatitis B Virus (HBV) Outbreak Transmission Analysis in Manitoba
Prevalence and Clinical Characteristics of Hepatitis Delta Virus (HDV) Infected Individuals in British Columbia
PSMA-Targeted Radionuclide Therapy of Hepatocellular Carcinoma in a Woodchuck Model
G4Q-binding ligands: a starting point for potential cure therapies for chronic hepatitis B infections
Cracking the HBV Code: Unravelling the specificity of SP1 with G-Quadruplex for next- generation cccDNA inhibitors
Effect of HBV treatment on all-cause and liver-related death among individuals with HBV and cirrhosis in British Columbia: a population-based cohort
Hepatitis B Virus Genotype (GT) Does Not Influence Virological and Enzymatic Measures Over Time
Prevalence of Hepatitis B Among Adults Receiving Immunosuppressive Therapy At a Tertiary Care Center in Saudi Arabia
Hepatocellular carcinoma (HCC) in patients followed in two clinics in Toronto
Experience of a Chinese Hepatitis B Peer Support Group (PSG): Successes and Challenges
Small molecules approach in HBV treatment:preventing transcription in the pre-core promoter by blocking a G-quadruplex with mithramycin and daunorubin
Kinetics of Quantitative HBsAg Decline in Chronic Hepatitis B Patients Receiving Nucleos(t)ide Antiviral Therapy
Opening the X-files: Exploring HBx protein’s role in transcriptional enhancement
Establishment of HBx responsive quantitative cell culture reporter system for monitoring HBV infection
Unravelling an important DNA knot – analysis of HBV’s promoter G4-quadruplex
Production of recombinant woodchuck surface antigen and antibodies for use in ELISAs, ELISpots, and western blots
Anchoring Hepatitis B: Investigation of HBV promoter binding with zinc finger Specificity protein 1 and G4-quadruplex binding drugs
Guanine quadruplexes and host transcription factor interactions: Targeting viral cccDNA to treat chronic HBV.
Guanine quadruplexes and host transcription factor interactions: Targeting viral cccDNA to treat chronic HBV.
Nikolas Shapka
Under Review
Profile Summary
| Submission ID | PRO7E1WTNLK |
|---|---|
| Name | Nikolas Shapka |
| Call | Progress toward Hepatitis B Elimination Meeting in Canada - Abstract Submission |
| Email Address | nshapka@ualberta.ca |
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| Organization |
Session
| Title | Guanine quadruplexes and host transcription factor interactions: Targeting viral cccDNA to treat chronic HBV. |
|---|---|
| Description | Guanine quadruplexes and host transcription factor interactions: Targeting viral cccDNA to treat chronic HBV. Nikolas Shapka 1, Kuldeep Kaur 2, Maulik Badmalia 1, Vanessa Meier-Stephenson 1-3 1 Department of Medicine, Division of Infectious Diseases, University of Alberta, Edmonton, AB; 2 Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB; 3 Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB Email: nshapka@ualberta.ca Background: The covalently-closed circular DNA (cccDNA) of chronic HBV contains a G4-quadruplex (G4Q), a DNA secondary structure comprised of stacked guanine tetrads. HBV’s G4Q recruits the host transcription factor Sp1 to facilitate viral transcription. We are exploring interference of this interaction. |
| Track | Hepatitis B (including HDV, HCV, HIV Co-infections) - Biomedical/Basic Science |
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